Bioactive Composite Material Based on Polyurethane with Isoniazid

An urgent task is the development of new implantation materials with a prolonged medicinal effect for treatment extrapulmonary form tuberculosis. The purpose this investigation was to obtain an material based on mesh polyurethane anti-tuberculosis drug isoniazid, study release isoniazid from polymer, biodegradation such materials, as well analyze cellular reactions their in body experimental animals. According results dynamics structure polyurethane, it shown that little more than 44% released polymer matrix during 389 days study. At same time, first 3 days, shock dose – 18%, which can be important reducing pathological process at location implant. When studying obtained established there redistribution supramolecular structures, type these structures remained unchanged, but size globular particles changed. In model environments, organization large, possibly hydrophobic, destruction fragments into large formations probably took place, reflected increase some physical and mechanical indicators. During implantation, subjected resorption due activity phagocytic fragments, loads, contributed removal products mass led decrease main parameters. test by histological methods, around samples rather pronounced long-lasting (up 1 month) reaction aseptic inflammation observed. composition connective tissue capsule indicated fairly good tolerability isoniazid. It bioactive composite promising implant bone joint